Structure‐function analysis of Editing Enzymes.
Jumping Genes
Structure‐function analysis points to a polynucleotide‐accommodating groove essential for APOBEC3A restriction activities.
The group of Prof. Didier Trono (LVG - Laboratory of Virology and Genetics) showed that the target-specificity of APOBEC3 family members - editing enzymes that can inhibit various mobile genetic elements - is partly defined by structural features influencing their interaction with polynucleotide substrates.
Yannick Bulliard et al., J. Virol., doi:10.1128/JVI.01651-10 (2010)