Sirtuins regulated by nutrient availability.
© 2011 EPFL
CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability.
The group of Prof. Johan Auwerx (LISP - Laboratory of Integrative Systems Physiology) in collaboration with researcher from Harvard, show that sirtuins (e.g. SIRT1) - a class of proteins that possess either histone deacetylase or mono-ribosyltransferase activity - expression is tightly controlled at the transcriptional level by nutrient availability and further underscore that SIRT1 is a crucial metabolic checkpoint connecting the energetic status with transcriptional programmes.
Lilia G Noriega et al., EMBO reports (2011) 12, 1069 - 1076, doi:10.1038/embor.2011.151