In vivo cyclic loading decrease bone resorption rate.
© 2011 EPFL
In vivo loading increases mechanical properties of scaffold by affecting bone formation and bone resorption rates.
The group of Prof. Dominique Pioletti (Biomechanical Orthopedics Laboratory EPFL-CHUV-DAL) investigated the role of in vivo loading on mechanical properties of bone scaffold. They studied the effect of mechanical stimulation on bone formation and resorption and showed that short period of loading enhances mechanical properties of bone scaffold by 60%. These data show for the first time that loading enhances bone formation rate initially and decreases bone resorption later. This work has been awarded the Presidential award of the Swiss Society of Bone and Mineral Research.
Alireza Roshan-Ghiasa et al., Bone doi:10.1016/j.bone.2011.09.040 (2011)