Control of centrosome duplication.
© Tous droits réservés par Blue Gav
The SCF–FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication.
In collaboration with german researchers, the group of Pierre Gönczy (SV ISREC UPGON ) show that centrosome duplication is regulated by the activity of an E3-ubiquitin ligase that employs the F-box protein FBXW5 as its targeting subunit. Depletion of endogenous FBXW5 or overexpression of an F-box-deleted mutant version results in centrosome overduplication and formation of multipolar spindles. Deregulated centrosome duplication can result in genetic instability and contribute to tumorigenesis.
Anja Puklowski et al., Nature Cell Biology, doi:10.1038/ncb2282 (2011)